Anti-Aging Guide

Resveratrol is the latest Antioxidant substance to hit the world wide market. Does it really deserve all the media attention it has attracted?

Resveratrol is a powerful antioxidant compound that may provide protection for a myriad of degenerative disorders. Studies have shown the many benefits of resveratrol for fat loss, cardiovascular health, reduction of insulin resistance, alzheimers, anti-carcinogenic, and its anti-inflammatory effect. It has also been shown to extend life span in mammals by as much as 15% (10 human years) by increasing the activity of sirtuins, which prolong the life span of living organisms.

This plant based anti-oxidant has been deemed the “modern elixir of youth”, mopping up free radicals and preventing oxidative damage associated with aging. Some of these activities have been implicated in the cardiovascular protective effects attributed to resveratrol and also to red wine.

Prior to 2002, there had been no previous studies describing the potential effects of resveratrol on lifespan extension. However in the last 5 years, several researchers have reported that resveratrol is a potent activator of sirtuin enzymatic activity, mimics the beneficial effects of caloric restriction, retards the aging process and increases longevity in a number of organisms.

In addition, resveratrol seems to be effective in delaying the onset of a variety of age-related diseases in mammals, such as rodents. Therefore, it is possible that resveratrol may play a role in extending life duration and may act as an anti-aging agent.

Resveratrol in high doses has been shown to extend lifespan in some studies in invertebrates and to prevent early mortality in mice fed a high-fat diet. In a US study, researchers examined the effect of a low dose of dietary resveratrol and a calorie restricted (CR) diet, on the lifespan of mice. They fed mice from middle age (14-months) to old age (30-months) either a control diet, a low dose of resveratrol, or a CR diet and examined genome-wide transcriptional profiles.

The researchers reported a striking transcriptional overlap of CR and

resveratrol in heart, skeletal muscle and brain. Both dietary interventions inhibited gene expression profiles associated with cardiac and skeletal muscle aging, and prevented age-related cardiac dysfunction. Dietary resveratrol also mimicked the effects of CR in insulin mediated glucose uptake in the muscle.

Gene expression profiling suggested that both CR and resveratrol might

retard some aspects of aging, through alterations in chromatin structure and transcription. Resveratrol, at doses that could be readily achieved in humans, as demonstrated to fulfill the definition of a dietary compound that mimicked some aspects of CR and retarded some aging parameters.

Resveratrol also possesses chemopreventive and chemotherapeutic properties and has been shown to increase lifespan in yeast and metazoans, including mice. Genetic evidence and in vitro enzymatic measurements indicate that the deacetylase Sir2/SIRT1, an enzyme promoting stress resistance and aging, is the target of resveratrol. Similarly, down-regulation of insulin-like pathways, of which PI3K (phosphoinositide 3-kinase) is a key mediator, promotes longevity and is an attractive strategy to fight cancer.

In France, Fröjdö S. et al showed that resveratrol inhibited, in vitro and in cultured muscle cell lines, class IA PI3K and its downstream signalling at the same concentration range at which it activated sirtuins. The observations defined class IA PI3K as a target of resveratrol that might contribute to the longevity-promoting and anticancer properties, and identified resveratrol as a natural class-specific PI3K inhibitor.

In the 1997 study reported in the journal Science, resveratrol was found to exhibit major inhibitory activity against cancer initiation, promotion and progression. Specifically, its antioxidant and anti-mutagenic potency and induction of phase II drug-metabolizing enzymes were seen as counter to carcinogenic initiation.

Resveratrol hindered cyclooxygenase and hydroperoxidase and initiated anti-inflammatory effects, thereby demonstrating anti-promotion activity. The induction of human promyelocytic leukemia cell differentiation by resveratrol also thwarted the progress of carcinogenic activity. In addition, resveratrol demonstrated significant inhibitory effects in vitro with carcinogen-induced preneoplastic lesions in mouse mammary glands, and in vivo with tumorogenesis in the two-stage mouse skin cancer model. The data suggests that resveratrol, a common constituent of the human diet, may be used as a potential cancer chemopreventive agent in humans.

Because of lack of early diagnosis and poor therapeutic responsiveness, median survival in patients with pancreatic cancer is less than 6 months, and survival beyond 5 years is rare. Thus, a novel dimension in chemotherapeutic agents for pancreatic cancer would be beneficial to control this metastatic disease. The effect of resveratrol in pancreatic cancer was investigated at Northwestern University Medical School in USA. The potential role of resveratrol was evaluated on pancreatic cancer cell proliferation using two human pancreatic cancer cell lines, PANC-1 and AsPC-1.

The result showed that resveratrol inhibited proliferation of both PANC-1 and AsPC-1. Cell number of both cancer cell lines was also significantly

decreased, following resveratrol treatment.

These findings suggest that resveratrol may have a potent anti-proliferative effect on human pancreatic cancer with induction of apoptosis. Hence resveratrol is likely to be valuable for the management and prevention of human pancreatic cancer.

In a published article in journal Nutrition, Japanese researchers found that resveratrol significantly reduced the tumour volume, tumour weight and metastasis to the lung in mice bearing highly metastatic Lewis lung carcinoma (LLC) tumours. In addition, resveratrol inhibited DNA synthesis most strongly in LLC cells, increased apoptosis in LLC cells, and decreased the S phase population. Resveratrol inhibited tumour-induced neovascularization in an in vivo model. Moreover, resveratrol significantly inhibited the formation of capillary-like tube formation from human umbilical vein endothelial cells (HUVEC), and the binding of vascular endothelial growth factor (VEGF) to HUVEC.

The researchers suggest that the anti-tumour and anti-metastatic activities of resveratrol might be due to the inhibition of DNA synthesis in LLC cells and the inhibition of LLC-induced neovascularization and tube formation (angiogensis) of HUVEC by resveratrol.

Resveratrol has strong antioxidative properties that have been associated with the protective effects of red wine consumption, against coronary heart disease, which is commonly known as “the French paradox”. In a Korean study, Jang J.H. and Surh Y.J. investigated the effects of resveratrol on beta-amyloid-induced oxidative cell death in cultured rat pheochromocytoma (PC12) cells. There has been compelling evidence supporting the idea that beta-amyloid-induced cytotoxicity is mediated through the generation of reactive oxygen intermediates (ROIs).

PC12 cells treated with beta-amyloid exhibited increased accumulation of intracellular ROI and underwent apoptotic death. Beta-amyloid treatment also led to the decreased mitochondrial membrane potential, the cleavage of poly(ADP-ribose)polymerase, an increase in the Bax/Bcl-X(L) ratio, and

activation of c-Jun N-terminal kinase.

Resveratrol was found to attenuate cytotoxicity, apoptosis, and intracellular ROI formation. The polyphenol also thwarted other effects of the beta-amyloid peptide, which is believed to account for the plaques that are characteristic of brain tissue in patients with Alzheimer’s disease.

In India, Palsamy P. and Subramanian S. carried out a study to evaluate the anti-diabetic properties of resveratrol in streptozotocin-nicotinamide induced experimental diabetes in rats. The diabetic rats orally treated with resveratrol for 30 days resulted in significant decrease in the levels of blood glucose, glycosylated hemoglobin, blood urea, serum uric acid, serum creatinine and diminished activities of pathophysiological enzymes such as aspartate transaminase, alanine transaminase and alkaline phosphatase.

The anti-hyperglycemic nature of resveratrol is also evidenced from the improvement in the levels of plasma insulin and haemoglobin. Further, the results are comparable with glyclazide, an oral standard anti-diabetic drug.

Thus, these findings suggest that resveratrol may be considered as an effective therapeutic agent for the treatment of diabetes mellitus.

Many studies have shown that resveratrol has anti-inflammatory properties, and it has been ascribed as having health benefits that help to prevent cancer and coronary heart disease. A treatment that combines anti-microbial and anti-inflammatory actions may be desirable for alleviating many skin conditions that range in severity.

In summary exhibits a number of biological activities in the human body. These include anti-inflammatory, antioxidant, anti-tumour, anti-hyperglycemic, anti-microbial and anti-carcinogenic properties. Resveratrol may also mimic the effects of calorie restriction and retard the aspects of aging.

Together with grape seed and red wine, resveratrol is a potent antioxidant boost, which helps to protect the body against free radical damage that is normally associated with premature aging and disease. It also supports a healthy cardiovascular and immune system for optimal wellness. You can find all these ingredients in this Resveratrol product.

When is HGH treatment recommended?

It seems like with each passing day there are more parents who are seeking for treatment for their children to receive growth hormone (GH) therapy. Usually they have waited for the child to grow and they concerned that theirs is lagging behind all their age mates. There is a syndrome today that seems to be the obsession with parents to have children who are taller, because of the issue of image and height; doctors will rarely recommend HGH therapy just for that reason. Pediatric endocrinologists advise that the children who would most likely benefit are those who are growing at a slow rate and not the short children as it were.

The advice given to any parents who are concerned about the development of their children is to consult first with their pediatrician before making conclusions. The pediatrician should be able to advice on which child exactly needs therapeutic intervention. The human growth hormone treatments currently available are only administered intravenously with a small needle where parents receive the training on how to do it. The majority of the patients begins their treatment at ages between 5 and 10 and may continue for several years.

Treatment of children with HGH deficiency

When doctors are sure your child needs treatment the therapy will involve replacement of the deficient human growth hormone. The usual form of administration is through an intra-muscular injection. However the needles are not as painful as would be anticipated and that makes the treatment bearable.  The benefits of the treatment are a little more pronounced in children than would be with adults, with a child usually showing signs of growth within just a few months of treatment.

The other benefits that will be seen will include an increase in body strength, progression of motor development and a reduction of body fat. Most children who respond well to the treatment are able to adjust doses of the HGH supplement downwards in about three to four months. On rare cases some may require to go on with the treatment for the rest of their lives. The greatest consideration for many people is the costs of the GH therapy which can go up to $30,000 per year.

Treating adults with HG therapy

There are a few benefits that can be accrued by severely GH deficient adults undergoing human growth hormone therapy.  Some of them include increased energy levels, strength and improved bone density. However, the effects of treatment on grownups that were basically healthy are not known to be so substantial and the side effects are known to be a little more than average. Some of the benefits seen in adults can be achieved by a good regular exercise regime, but since many people like short cuts, there has been in influx of anti-aging clinics, with very little tangible results.

Related Articles

Top rated HGH Product

HGH Facts

Scientists, dermatologists and plastic surgeons have discovered after years of research that a variety of natural ingredients and vitamin extracts significantly help slow down and even reverse the signs of aging. These ingredients can now be found in many anti-aging skin care products that are recommended physician developed and physician recommended, which are specified below.

Alpha Hydroxy Acids (AHAs) – AHAs help to smooth fine lines and wrinkles, as well as improve skin tone and texture. AHAs also assist in unblocking and cleansing pores and improving skin condition in general. Oily skin or acne ban also benefit from its use.

Copper Peptides are the latest scientific breakthrough in skin rejuvenation. Copper has been found to naturally firm the skin, enhance elasticity, and reduce fine lines and wrinkles.

Glycolic Acid – Glycolic acid is an Alpha-Hydroxy-Acid (AHA). It is the most beneficial AHA in skin care. On absorption into the skin cells, Glycolic acid triggers production of collagen which plumps up skin cells helping to reduce wrinkles on the skin’s surface. Glycolic acid is also proven to be very effective in the treatment of acne.

Green Tea Extract – Green tea has anti-inflammatory and anti-growth qualities and it is found in many skin care products that are designed to reduce the appearance of puffiness, wrinkles, fine lines and large pores.

N-6 furfuryladenine (kinetin) – Furfuryladenine is a nature-identical plant growth factor. It retards the aging of plant cells. As a natural, anti-aging ingredient, it has been proven to reduce wrinkles and fine lines. Furfuryladenine is a proven alternative for people with sensitive skin or people who are sensitive to products containing Retinol and Vitamin C.

Pal-KTTKS is a modified chain of five amino acids developed as a cosmetic active ingredient. Pal-KTTKS is an effective ingredient for reducing fine lines and wrinkles. It is found to promote a smoother, younger complexion quickly, without expensive and painful chemical peels, surgery or injections.

Tissue Nutrient Solution (TNS) – TNS is a tissue repairing complex containing growth factors found in normal, healthy skin. TNS is promoted as the next level of skin rejuvenation that delivers dramatic results, for smoother, softer, younger looking skin.

Vitamin A (Retinol)- It has been suggested that Vitamin A helps to build collagen fibers within the skin. Vitamin A also has an exfoliating property. Because of this Vitamin A is beneficial in minimizing the appearance of fine wrinkle lines

Vitamin C – Vitamin C or ascorbic acid acts as an antioxidant and is considered vital in wound healing as it assists in stabilizing collagen. When applied topically (as a cream), vitamin C can reduce fine lines and wrinkles and can lessen the severity of sunburn.

Vitamin E – Vitamin E is also an antioxidant which can have anti-inflammatory effects on the skin. When applied topically, vitamin E has been shown to improve moisturization, softness and smoothness and to provide modest protection from sunlight.

Because every individual’s skin is different, different anti-aging products will have differing results for each individual. It is therefore important that you choose a skin care regimen and products that make you feel completely comfortable with the look and feel of your skin.

Be patient, there are no antiaging products available that provide instant results. The process is gradual and generally it will take between one to two months before you will start to see real benefits. Some products may initially cause a reaction with your skin, such as redness or itchiness. Generally these disappear within a few days, if symptoms persist or worsen you should stop using the product and seek advice from a professional.

Providing you allow the proper time for the products to take effect and properly follow product directions, you are sure notice significant improvements in the appearance of your skin.

Anti aging natural supplements are basically meant to make up for deficiencies in the human diet. Supplements have always been recognized for being beneficial but never before than in the case of anti aging. Although it has been scientifically proven that anti aging natural supplements have helped to avert many of the conditions associated with old age, it is important to realize that these supplements cannot get the job done on their own.

There are a few different ingredients that you want to make sure to look for when shopping for anti aging natural supplements, one in particular being Vitamin E, which has long been considered as being the most important agent in countering free radicals. This is important because these free radicals attack a variety of molecules including the DNA, lipids and proteins in our skin, and as a result can damage the actual structure of cell membranes and leave the skin looking dull and lifeless.

Besides Vitamin E you want to find anti aging natural supplements that contain antioxidants, as these also help to fight free radicals. Vitamin C and beta-carotene are also well-documented antioxidants, and are found in most anti-wrinkle products available today.

Lyopic acid is another antioxidant to look for in anti aging natural supplements, and it is one that is usually found in tomatoes and tomato based products. Lycopene is required in certain organs in the body such as the prostate and liver, and it even helps to protect against cancer in the digestive tract.

Research has proven time and time again that these antioxidants can form a successful defense against free radicals, and they work by intercepting free radicals to prevent them from damaging blood vessel membranes, which in turn results in helping the flow of blood to the heart and brain.

Live Right

Besides taking anti aging natural supplements there are ton of other things that you can do to keep yourself looking and feeling young. It is important that you eat a healthy well-balanced diet and drink plenty of water, at least six to eight glasses a day. You should also get at least a half hour of physical activity a day to keep yourself healthy and in shape.

Eating the right foods and getting lots of exercise will help you to live a longer, healthier life, and not only that but as well it will keep you looking your best. It has also been shown that many illnesses such as diabetes and heart disease can be controlled or even prevented by living right.

People do not realize what vitamins can do for them. Vitamins are great for those who need them. On the other hand, if you have sufficient vitamins, then you will not need regimens of vitamins. Building vitamins in your system, which has too much already, or sufficient nutrients can cause harm. Vitamins will make you look younger and feel younger as well as make you feel good about yourself, providing you need regimens suited for your system.

How do I learn what vitamins are good for me? We get natural vitamins in the foods we eat. Some times, you do not get the right amount so you have to take vitamins, which come in many ways. You can get them in a pill form, liquid, powder, etc. If the vitamins you choose do not work for you, your doctor can give you a shot. You can get almost all the vitamins you may need at local drug stores. You will find vitamins at supermarkets, department stores and so on. If you cannot determine which vitamins are right for you, check with your doctor. He may have some recommendations. In fact, you should visit your family doctor first and ask him/her, which vitamins may be suitable for your body type.

How vitamins help you to relieve stress. Vitamins will help control your weight, and help keep you from getting sick with the common cold and the flu. There are many vitamins to help you out. You can check out at your local pharmacy many different kinds. You pharmacist is your best friend as well as your doctor. He/she may be able to help you find out which vitamins are best suited for your body type.

What kinds of vitamins should I consider and for what purpose? You have a wide array of vitamins to choose from, including B1, B12, B6, E, D, K, A, and so on. B1 is designed to help your heart function in order. The vitamin will assist your central nervous system as well, helping you to have a better attitude in life. B1 will give you energy, since it is known to swap blood sugar, transferring it to energy. B1 promotes a healthy mucous membrane, and will promote the muscular and cardio functions.

How do you decide if you need vitamins? Some things that you may feel if you are low on vitamins are fatigue. You may feel muscle tenderness, or experience insomnia. Insomnia can benefit from Melatonin supplements. You can get natural vitamins from corn breads, nuts, oatmeal, cereal, wheat and so on. Eat plenty of veggies and fruits also to get the vitamins you need.

If you have colds, you can benefit from Vitamin C. If you are searching for anti-aging vitamins consider E, since According to experts, Vitamin E is responsible for preserving oxygen in the blood, reduce more than 40 percent of the oxygen amount the heart needs as well. Vitamin E also has been linked to influential anti-coagulants. Some experts believe the vitamin will slow blood clotting by dilating the blood vessels. If you searching for the vitamin to help you stay young and healthy, then Vitamin E that contains 200 units is for you.

According to German experts Wolf and Luczak Vitamin E is a stabilizer for youth and strong blood. If this is true, then dying cells will be replaced quickly by new cells. Dying cells is responsible for many diseases, including cancer, AIDS, HIV, leukemia and so on. In fact, T-Cells that deteriorate is responsible for AIDS, certain types of cancers, herpes simplex, and so on.

Most of all it is very important to find a diet plan that works for you. You need to feel comfortable with what you eat. Supplements, like the proven liquid multivitamins are very popular in the fitness industry because they boost energy, vitality, and weight loss.

Why supplement with liquid multi-vitamins? They absorb 90 percent better into the body’s system, and with junk food readily available to Americans, we need all the help we can possibly get! Vanessa Alexander is an expert on health and wellness, and alternative herbal intervention. Why not treat your body right and look great in 2008!

Spring water bottled by virtually every company in the bottled water industry labels their product with information that is misleading at best.  The industry has tripled over the last decade and the growth curve is as a result of an aggressive campaign by the industry to convince consumers that city or public tap water is downright dangerous when, in fact, public water supplies are safer.  Believe it or not there are several companies, companies that are very recognizable, that have been severely penalized by the FDA for with extracting water right out of the river (one from the Potomac River near Washington D.C.) or right from the tap on city water lines. Don’t misunderstand the intent of this article as “railing” on the bottled water industry.  This industry has saved many lives around the world in disaster and war torn areas.  The point here is to provide the truth and eliminate the scare tactics that causes you to spend money unnecessarily.

Spring water is water that is derived from an underground formation from which water flows naturally to the surface of the earth. Spring water must be collected only at the spring or through a borehole tapping the underground formation feeding the spring. Spring water collected with the use of an external force must be from the same underground stratum as the spring and must have all the physical properties before treatment, and be of the same composition and quality as the water that flows naturally to the surface of the earth.

Just the fact that a spring water bottling water company has extracted that water from a spring it doesn’t mean that chemicals weren’t added.  The possibility exists that spring water can pick up contaminants whole being transported in large over-the-road tanks.  It can still be contaminated by acid rain, industrial pollution, or parasites.  A label on a bottle that says “spring water” doesn’t necessarily mean that it is natural, safe, healthy, and pure.  One of the aspects of FDA regulations that govern the standards of the bottled water industry is that they don’t regulate the companies that package and sell bottled water in the same state (which is 60-70% of all water sold in the U.S.).  This means that one in five states doesn’t regulate this water.  Observe some of the labels below of several companies that caused the FDA to take regulatory action in 1995 that drive home this point;

“Spring Water” (with a picture of a lake surrounded by mountains on the label) — Was actually from an industrial parking lot next to a hazardous waste site.

Alasika™ — “Alaska Premium Glacier Drinking Water: Pure Glacier Water From the Last Unpolluted Frontier, Bacteria Free” — Apparently came from a public water supply. This label has since been changed after FDA intervention.

Vals Water — “Known to Generations in France for its Purity and Agreeable Contribution to Health . . . Reputed to Help Restore Energy, Vitality, and Combat Fatigue” — The International Bottled Water Association voluntary code prohibits health claims, but some bottlers still make such claims.

If one can’t be sure then if bottled water is safe, what is the alternative?  How about tap water?  This question alone makes most people freeze at the notion so let me enlighten you with the facts.  The following conditions for bottled water are not required by the FDA; disinfection, confirmation of the absence of E. Coli and Fecal Coliform, filter removal of pathogens, and testing for Cryptosporidium, Giardia, and viruses.  These are all required by the EPA for tap water but not for bottled water.  Surprising wouldn’t you say?  Another consideration; the testing frequency for bacteria in tap water is hundreds of times per month where bottled water is once per week.  Testing for synthetic organic chemicals for tap water is once per quarter whereas bottled water is once per year.  What’s even worse is that carbonated and seltzer waters follow none of the aforementioned guidelines or standards.  So the next time you purchase bottled spring water thinking it is the answer to the tap water, do remember that the FDA standards that govern the bottled water industry aren’t as strict as EPA standards for tap water.

Marketing is very powerful tool to sell products.  Now that we know that bottled water is not necessarily purified water my suggestion is to acquire the city water testing standards and results to be safe but purchase a carbon block filter/uv light purification water treatment system for your home drinking water.

Are you interested in receiving a free customized health analysis and anti-aging report? By going to the website you will gain first access to the most powerful Anti-Aging drink on the market “AgelessXtra”. Go to http://naturalcellrenewal.com to pick up this valuable information while gaining access to the newest Health Drink and Energy Drink AgelessXtra.

Is HGH Safe?

As you might well know as we continue climbing the ladder of age, the body loses the ability to burn all the fat it should and at the same time loses the muscle mass it should have. It is like for every pound of muscle you lose you get a similar amount of fat. The right thing to do then is to get a way of dealing with those extra pounds of fat. Many people at this stage consider HG treatment.

The pituitary gland secretes the natural human growth hormone throughout our lives to control growth among other things. When we are grown up the HGH takes control of body metabolism to keep everything at optimum. As we get older the body stops producing enough HG hormone and so the metabolic rate goes down, leading to fatigue, weight gain, hypertension and man other ailments we associate with age. So choosing to get HGH supplementation simply appeals to anyone.

There are risks and complications you need to know about

The truth of the matter is that almost every single supplement has some side effect whether big or small and the best way to do anything would be to go the natural way. The trouble is that there times when the natural is going to fail and you will need some intervention to get the results you are looking for. That means that you need to cultivate the right environment and circumstances so that you grow naturally because it is the only way without any side effects.

Any real therapy dealing with the human growth hormone will come with a few side effects which you will need to consider because even though they are minor, our different body make-up means that they all affect us in different ways as individuals. One of the greatest risks of using HGH is said to be the risk of getting diabetes.  Other risks will include things such as muscle stiffness, tenderness, soreness, coldness in the hands and other parts of the body.

Consult your doctor

That means then that for you to be sure of what to expect when it comes to HGH treatment, you need to consult with your physician before you begin any kind of therapy. Some doctors know much about some lines of HGH therapy and will be able to advice you accordingly. Just make sure the doctor you consult knows about the therapy you want to use.

Dosage

The next thing you will want to be careful about is the dosage of the HGH treatment you are considering. Those who take higher doses, whether deliberately or by mistake place themselves at a higher risk. If you are just beginning to experiment with the human growth hormone therapy, it is advisable that you start slow.  You can begin by taking at least 25% of the indicated dosage as you build up your way to taking a complete dose.

Related Articles

Top rated HGH Product.

HGH Anti Aging.